The film depicts a story of a looming war between aristocratic vampires and savage, brutal werewolves for dominance in the underworld. In their ceaseless pursuit for survival supremacy, these two factions, the refined vampires and the ruthless werewolves, are always on the lookout for opportunities to eliminate each other, leading to an imminent and explosive conflict.

The story unfolds in the late 19th century, where the vampire Count Dracula has long been entrenched in the ancient town of Transylvania. Dracula has drained the blood of countless humans and is determined to secure eternal life for himself and the descendants of his three vampire brides. Under the sinister influence of Dracula's vampire family, God has promised the Van Helsing family that unless they eliminate Dracula, their souls will not ascend to heaven, as they are tasked with eradicating the evil that Dracula embodies.